Endothelial NO Production Is Mandatory for Epigallocatechin-3-Gallate–induced Vasodilation

Endothelial NO Production Is Mandatory for Epigallocatechin-3-Gallate–induced Vasodilation: Results From eNOS Knockout (eNOS−/−) Mice

The underlying mechanisms for the vasodilating effects of the tea catechin epigallocatechin-3-gallate (EGCG) are still not fully understood. Besides nitric oxide (NO)-dependent effects, other modes of action are discussed. To elucidate whether the NO pathway is a prerequisite in mediating vasodilating effects, we investigated EGCG-induced vasorelaxation in isolated aortic rings of endothelial n...

Vascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms

Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 C alleles and VEGF production by LPS-stimulated PBMCs was investigated. In addition; the relationship ...

Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.

The lysine acetylation state of nonhistone proteins may be regulated through histone deacetylases (HDACs). Evidence suggests that nitric oxide (NO) synthase 3 (NOS3; endothelial NOS) is posttranslationally lysine acetylated, leading to increased NO production in the endothelium. We tested the hypothesis that NOS3 is lysine acetylated and that upregulated HDAC1-mediated deacetylation leads to re...

Cover for Volume.13, No.3

Inhaled NO and pulmonary vasodilation.

To the Editor: Hare et al concluded that inhaled nitric oxide (NO) caused selective pulmonary vasodilation in patients receiving left ventricular assist device support and that this accounted for the increase in mean left atrial pressure, which they considered a beneficial hemodynamic effect. The evidence for pulmonary vasodilation was that pulmonary vascular resistance (PVR) decreased. However...